1eix Summary

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STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM E. COLI, CO-CRYSTALLISED WITH THE INHIBITOR BMP

The structure was published by Harris, P., Poulsen, J.C.N., Jensen, K.F., and Larsen, S., in 2000 in a paper entitled "Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE P08244 (1-245) (PYRF_ECOLI)search Escherichia coli K-12search 100% 245 94%
B OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE P08244 (1-245) (PYRF_ECOLI)search Escherichia coli K-12search 100% 245 94%
C OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE P08244 (1-245) (PYRF_ECOLI)search Escherichia coli K-12search 100% 245 94%
D OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE P08244 (1-245) (PYRF_ECOLI)search Escherichia coli K-12search 100% 245 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08244 (1 - 245) OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P08244) Decarboxylasesearch Aldolase class Isearch PF00215: Orotidine 5'-phosphate decarboxylase / HUMPS familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P08244) 'de novo' UMP biosynthetic processsearch 'de novo' pyrimidine nucleobase biosynthetic processsearch metabolic processsearch pyrimidine nucleotide biosynthetic processsearch nucleobase-containing small molecule interconversionsearch orotidine-5'-phosphate decarboxylase activitysearch catalytic activitysearch carboxy-lyase activitysearch lyase activitysearch protein bindingsearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D Orotidine 5'-phosphate decarboxylase domainsearch Ribulose-phosphate binding barrelsearch Aldolase-type TIM barrelsearch Orotidine 5'-phosphate decarboxylasesearch Orotidine 5'-phosphate decarboxylase, active sitesearch