1ehi Summary

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D-ALANINE:D-LACTATE LIGASE (LMDDL2) OF VANCOMYCIN-RESISTANT LEUCONOSTOC MESENTEROIDES

The structure was published by Kuzin, A.P., Sun, T., Jorczak-Baillass, J., Healy, V.L., Walsh, C.T., and Knox, J.R., in 2000 in a paper entitled "Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.38 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of D-ALANINE:D-LACTATE LIGASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A D-ALANINE:D-LACTATE LIGASE Q03ZI1 (1-377) (DDL_LEUMM)search Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293search 100% 377 95%
B D-ALANINE:D-LACTATE LIGASE Q03ZI1 (1-377) (DDL_LEUMM)search Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293search 100% 377 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q03ZI1 (1 - 377) D-ALANINE:D-LACTATE LIGASE Leuconostoc mesenteroides

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q03ZI1) D-Alanine ligase N-terminal domainsearch, ATP-binding domain of peptide synthetasessearch Rossmann foldsearch, ATP-grasp fold, B domainsearch, ATP-grasp fold, A domainsearch PF01820: D-ala D-ala ligase N-terminussearch, PF07478: D-ala D-ala ligase C-terminussearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q03ZI1) metal ion bindingsearch ATP bindingsearch ligase activitysearch nucleotide bindingsearch D-alanine-D-alanine ligase activitysearch manganese ion bindingsearch magnesium ion bindingsearch catalytic activitysearch cytoplasmsearch peptidoglycan biosynthetic processsearch regulation of cell shapesearch cell wall organizationsearch

Chain InterPro annotation
A, B D-alanine--D-alanine ligase/VANA/B/C, conserved sitesearch D-alanine--D-alanine ligasesearch D-alanine--D-alanine ligase, C-terminalsearch D-alanine--D-alanine ligase, N-terminal domainsearch ATP-grasp foldsearch ATP-grasp fold, subdomain 1search ATP-grasp fold, subdomain 2search Pre-ATP-grasp domainsearch