1eh6 Summary

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HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE

The structure was published by Daniels, D.S., Mol, C.D., Arvai, A.S., Kanugula, S., Pegg, A.E., and Tainer, J.A., in 2000 in a paper entitled "Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE. This molecule has the UniProt identifier P16455 (MGMT_HUMAN)search. The sample contained 207 residues which is 100% of the natural sequence. Out of 207 residues 168 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE P16455 (1-207) (MGMT_HUMAN)search Homo sapienssearch 100% 207 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P16455 (1 - 207) O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P16455) Methylated DNA-protein cysteine methyltransferase, C-terminal domainsearch, Methylated DNA-protein cysteine methyltransferase domainsearch O6-alkylguanine-DNA Alkyltransferase; Chain A, domain 1search, "winged helix" repressor DNA binding domainsearch PF01035: 6-O-methylguanine DNA methyltransferase, DNA binding domainsearch, PF02870: 6-O-methylguanine DNA methyltransferase, ribonuclease-like domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P16455) DNA repairsearch response to drugsearch cellular response to DNA damage stimulussearch DNA ligationsearch response to organic cyclic compoundsearch methylationsearch cellular response to oxidative stresssearch DNA dealkylation involved in DNA repairsearch response to toxic substancesearch cellular response to organic cyclic compoundsearch regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch negative regulation of cell deathsearch response to ethanolsearch DNA methylationsearch response to folic acidsearch positive regulation of DNA repairsearch cellular response to ionizing radiationsearch mammary gland epithelial cell differentiationsearch catalytic activitysearch DNA-methyltransferase activitysearch methylated-DNA-[protein]-cysteine S-methyltransferase activitysearch methyltransferase activitysearch metal ion bindingsearch DNA bindingsearch calcium ion bindingsearch transferase activitysearch nucleussearch membranesearch nucleoplasmsearch

Chain InterPro annotation
A Methylated-DNA-[protein]-cysteine S-methyltransferase, active sitesearch Methylguanine DNA methyltransferase, ribonuclease-like domainsearch Winged helix-turn-helix DNA-binding domainsearch Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA bindingsearch