1efn Summary

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HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN

The structure was published by Lee, C.H., Saksela, K., Mirza, U.A., Chait, B.T., and Kuriyan, J., in 1996 in a paper entitled "Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely FYN TYROSINE KINASE and HIV-1 NEF PROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FYN TYROSINE KINASE P06241 (86-143) (FYN_HUMAN)search Homo sapienssearch < 90% 59 96%
C FYN TYROSINE KINASE P06241 (86-143) (FYN_HUMAN)search Homo sapienssearch < 90% 59 96%
B HIV-1 NEF PROTEIN P03406 (54-205) (NEF_HV1BR)search Human immunodeficiency virus type 1 (BRU ISOLATE)search < 90% 152 68%
D HIV-1 NEF PROTEIN P03406 (54-205) (NEF_HV1BR)search Human immunodeficiency virus type 1 (BRU ISOLATE)search < 90% 152 68%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06241 (86 - 143) FYN TYROSINE KINASE Homo sapiens
P03406 (54 - 205) HIV-1 NEF PROTEIN Human immunodeficiency virus 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C SH3-domainsearch SH3 Domainssearch SH3 domainsearch
B, D Regulatory factor Nefsearch Nef Regulatory Factorsearch Negative factor, (F-Protein) or Nefsearch

Chain ID Molecular function (GO)
B, D (P03406) GTP bindingsearch

Chain InterPro annotation
A, C SH3 domainsearch
B, D HIV negative factor Nefsearch HIV-1 Nef protein, core domainsearch