1efe Summary



The structure was published by Cho, Y., Chang, S.G., Choi, K.D., Shin, H., Ahn, B., and Kim, K.S., in 2000 in a paper entitled "Solution Structure of an Active Mini-Proinsulin, M2PI: Inter-chain Flexibility is Crucial for Insulin Activity" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of MINI-PROINSULIN. This molecule has the UniProt identifier P01308 (INS_HUMAN)search. The sample contained 60 residues which is < 90% of the natural sequence. Out of 60 residues 60 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MINI-PROINSULIN P01308 (25-54) (INS_HUMAN)search ,
P01308 (90-110) (INS_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
100% ,
60 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (25 - 54) MINI-PROINSULIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P01308) Insulin-likesearch Insulin-like, subunit Esearch PF00049: Insulin/IGF/Relaxin familysearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P01308) hormone activitysearch extracellular regionsearch

Chain InterPro annotation
A Insulinsearch Insulin-likesearch Insulin familysearch Insulin, conserved sitesearch