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CRYSTAL STRUCTURE OF HUMAN CATHEPSIN X

X-ray diffraction
2.67Å resolution
PDB entry 1ef7 coloured by chain, front view.
PDB entry 1ef7 coloured by chain, side view.
PDB entry 1ef7 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin Z
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Multimeric state: monomeric
Accessible surface area: 11508.93 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193667
Assembly 2
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Assembly Name: Cathepsin Z
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Multimeric state: monomeric
Accessible surface area: 11561.23 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-193667
Assembly 3
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Assembly Name: Cathepsin Z
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Multimeric state: homo dimer
Accessible surface area: 19353.83 Å2
Buried surface area: 3717.01 Å2
Dissociation area: 1,858.51 Å2
Dissociation energy (ΔGdiss): 12.14 kcal/mol
Dissociation entropy (TΔSdiss): 13.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-193668

Macromolecules

Cathepsin Z
Chains: A, B
Length: 242 amino acids
Theoretical weight: 27.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UBR2 (Residues: 62-303; Coverage: 86%)
Gene name: CTSZ
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
SCOP: Papain-like
Cathepsin Z in PDB entry 1ef7, assembly 1, front view.
Cathepsin Z in PDB entry 1ef7, assembly 1, side view.
Cathepsin Z in PDB entry 1ef7, assembly 1, top view.
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