1eag Summary


Secreted aspartic proteinase (SAP2) from Candida albicans complexed with A70450

The structure was published by Cutfield, S.M., Dodson, E.J., Anderson, B.F., et al., Marshall, C.J., Sullivan, P.A., and Cutfield, J.F., in 1995 in a paper entitled "The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of ASPARTIC PROTEINASE (SAP2 GENE PRODUCT). This molecule has the UniProt identifier P0CS83 (CARP2_CANAX)search. The sample contained 342 residues which is 90% of the natural sequence. Out of 342 residues 339 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ASPARTIC PROTEINASE (SAP2 GENE PRODUCT) P0CS83 (57-398) (CARP2_CANAX)search Candida albicanssearch 90% 342 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0CS83 (57 - 398) ASPARTIC PROTEINASE (SAP2 GENE PRODUCT) Candida albicans

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0CS83) Pepsin-likesearch Acid Proteasessearch PF00026: Eukaryotic aspartyl proteasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P0CS83) proteolysissearch extracellular regionsearch hydrolase activitysearch aspartic-type endopeptidase activitysearch peptidase activitysearch

Chain InterPro annotation
A Aspartic peptidasesearch Aspartic peptidase, active sitesearch Aspartic peptidase domainsearch