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HslV-HslU from E.coli

Source organism: Escherichia coli BL21(DE3)
Biochemical function: identical protein binding
Biological process: proteolysis involved in protein catabolic process
Cellular component: HslUV protease complex

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EC 3.4.25.2: HslU--HslV peptidase

Reaction catalysed:
ATP-dependent cleavage of peptide bonds with broad specificity.
Systematic name:
-
Alternative Name(s):
  • ATP-dependent HslV-HslU proteinase
  • Caseinolytic protease X
  • Caseinolytic proteinase X
  • ClpQ
  • ClpXP ATP-dependent protease
  • ClpXP protease
  • ClpXP serine proteinase
  • ClpYQ
  • ClpYQ protease
  • Escherichia coli ClpXP serine proteinase
  • HslUV
  • HslUV protease
  • HslUV proteinase
  • HslV peptidase
  • HslV-HslU
  • HslVU protease
  • HslVU proteinase
  • Protease ClpYQ
  • Protease CodWX
  • Protease HslVU
  • Proteinase ClpYQ
  • Proteinase HslUV

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. ATP-dependent protease subunit HslV
The deposited structure of PDB entry 1e94 contains 4 copies of Pfam domain PF00227 (Proteasome subunit) in ATP-dependent protease subunit HslV. Showing 1 copy in chain A.

PF07724
Domain description: AAA domain (Cdc48 subfamily)
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
The deposited structure of PDB entry 1e94 contains 2 copies of Pfam domain PF07724 (AAA domain (Cdc48 subfamily)) in ATP-dependent protease ATPase subunit HslU. Showing 1 copy in chain F.

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
The deposited structure of PDB entry 1e94 contains 2 copies of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in ATP-dependent protease ATPase subunit HslU. Showing 1 copy in chain F.

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. ATP-dependent protease subunit HslV
IPR022281
Domain description: ATP-dependent protease, HslV subunit
Occurring in:
  1. ATP-dependent protease subunit HslV
IPR019489
Domain description: Clp ATPase, C-terminal
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
IPR004491
Domain description: Heat shock protein HslU
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. ATP-dependent protease subunit HslV
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. ATP-dependent protease subunit HslV
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
The deposited structure of PDB entry 1e94 contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in ATP-dependent protease ATPase subunit HslU. Showing 1 copy in chain F.
3.60.20.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Occurring in:
  1. ATP-dependent protease subunit HslV
The deposited structure of PDB entry 1e94 contains 4 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in ATP-dependent protease subunit HslV. Showing 1 copy in chain A.
1.10.8.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: Helicase, Ruva Protein; domain 3
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
The deposited structure of PDB entry 1e94 contains 2 copies of CATH domain 1.10.8.60 (Helicase, Ruva Protein; domain 3) in ATP-dependent protease ATPase subunit HslU. Showing 1 copy in chain F.
1.10.8.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: DNA helicase RuvA subunit, C-terminal domain
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
The deposited structure of PDB entry 1e94 contains 2 copies of CATH domain 1.10.8.10 (Helicase, Ruva Protein; domain 3) in ATP-dependent protease ATPase subunit HslU. Showing 1 copy in chain F.
SCOP SCOP annotations
56251
Class: Alpha and beta proteins (a+b)
Fold: Ntn hydrolase-like
Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Occurring in:
  1. ATP-dependent protease subunit HslV
The deposited structure of PDB entry 1e94 contains 4 copies of SCOP domain 56251 (Proteasome subunits) in ATP-dependent protease subunit HslV. Showing 1 copy in chain A.
81269
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. ATP-dependent protease ATPase subunit HslU
The deposited structure of PDB entry 1e94 contains 2 copies of SCOP domain 81269 (Extended AAA-ATPase domain) in ATP-dependent protease ATPase subunit HslU. Showing 1 copy in chain F.

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