1e8c Summary

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STRUCTURE OF MURE THE UDP-N-ACETYLMURAMYL TRIPEPTIDE SYNTHETASE FROM E. COLI

The structure was published by Gordon, E.J., Flouret, B., Chantalat, L., Van Heijenoort, J., Mengin-Lecreulx, D., and Dideberg, O., in 2001 in a paper entitled "Crystal Structure of Udp-N-Acetylmuramoyl-L-Alanyl-D-Glutamate: Meso-Diaminopimelate Ligase from Escherichia Coli" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE P22188 (2-495) (MURE_ECOLI)search Escherichia coli K-12search 100% 498 99%
B UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE P22188 (2-495) (MURE_ECOLI)search Escherichia coli K-12search 100% 498 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22188 (2 - 495) UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P22188) MurE/MurF N-terminal domainsearch, MurCDEF C-terminal domainsearch, MurCDEFsearch Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1search, UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligasesearch, Protein-Tyrosine Phosphatase; Chain Asearch PF01225: Mur ligase family, catalytic domainsearch, PF02875: Mur ligase family, glutamate ligase domainsearch, PF08245: Mur ligase middle domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P22188) ATP bindingsearch UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activitysearch nucleotide bindingsearch ligase activitysearch acid-amino acid ligase activitysearch peptidoglycan biosynthetic processsearch cell divisionsearch biosynthetic processsearch regulation of cell shapesearch cell wall organizationsearch cell cyclesearch cytoplasmsearch

Chain InterPro annotation
A, B Mur ligase, N-terminalsearch Mur ligase, C-terminalsearch UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligasesearch Mur ligase, centralsearch