1e8a Summary



The structure was published by Moroz, O.V., Antson, A.A., Murshudov, G.N., et al., Skibshoj, I., Lukanidin, E.M., and Bronstein, I.B., in 2001 in a paper entitled "The Three-Dimensional Structure of Human S100A12" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of S100A12.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S100A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
B S100A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P80511 (2 - 92) S100A12 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P80511) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P80511) RAGE receptor bindingsearch calcium ion bindingsearch copper ion bindingsearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch extracellular regionsearch plasma membranesearch cytoskeletonsearch membranesearch cytoplasmsearch cytosolsearch nucleussearch innate immune responsesearch xenobiotic metabolic processsearch positive regulation of inflammatory responsesearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch monocyte chemotaxissearch positive regulation of MAP kinase activitysearch inflammatory responsesearch neutrophil chemotaxissearch defense response to fungussearch positive regulation of NF-kappaB transcription factor activitysearch killing of cells of other organismsearch immune system processsearch defense response to bacteriumsearch mast cell activationsearch cytokine secretionsearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch