1e7v Summary


Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine

The structure was published by Walker, E.H., Pacold, M.E., Perisic, O., et al., Hawkins, P.T., Wymann, M.P., and Williams, R.L., in 2000 in a paper entitled "Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin, and Staurosporine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT. This molecule has the UniProt identifier O02697 (PK3CG_PIG)search. The sample contained 961 residues which is < 90% of the natural sequence. Out of 961 residues 850 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT O02697 (144-1102) (PK3CG_PIG)search Sus scrofasearch < 90% 961 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Ras-binding domain, RBDsearch, Phoshoinositide 3-kinase (PI3K) helical domainsearch, PLC-like (P variant)search, Phoshoinositide 3-kinase (PI3K), catalytic domainsearch Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1search, C2- domain Calcium/lipid binding domainsearch, Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4search, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 5search Phosphatidylinositol 3- and 4-kinasesearch, Phosphoinositide 3-kinase family, accessory domain (PIK domain)search, Phosphoinositide 3-kinase C2search, PI3-kinase family, ras-binding domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (O02697) phosphatidylinositol phosphorylationsearch phosphatidylinositol-mediated signalingsearch transferase activity, transferring phosphorus-containing groupssearch phosphotransferase activity, alcohol group as acceptorsearch

Chain InterPro annotation
A C2 domainsearch Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainsearch Phosphatidylinositol 3-/4-kinase, catalytic domainsearch Phosphoinositide 3-kinase, accessory (PIK) domainsearch Phosphatidylinositol 3-kinase, C2 domainsearch Protein kinase-like domainsearch Phosphatidylinositol Kinasesearch Armadillo-type foldsearch Phosphatidylinositol 3/4-kinase, conserved sitesearch Ubiquitin-related domainsearch