1e7q Summary

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GDP 4-KETO-6-DEOXY-D-MANNOSE EPIMERASE REDUCTASE S107A

The structure was published by Rosano, C., Bisso, A., Izzo, G., et al., Sturla, L., De Flora, A., and Bolognesi, M., in 2000 in a paper entitled "Probing the Catalytic Mechanism of Gdp-4-Keto-6-Deoxy-D-Mannose Epimerase/Reductase by Kinetic and Crystallographic Characterization of Site-Specific Mutants" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of GDP-FUCOSE SYNTHETASE. This molecule has the UniProt identifier P32055 (FCL_ECOLI)search. The sample contained 321 residues which is 100% of the natural sequence. Out of 321 residues 314 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GDP-FUCOSE SYNTHETASE P32055 (1-321) (FCL_ECOLI)search Escherichia coli K-12search 100% 321 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P32055 (1 - 321) GDP-FUCOSE SYNTHETASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P32055) Tyrosine-dependent oxidoreductasessearch NAD(P)-binding Rossmann-like Domainsearch, UDP-galactose 4-epimerase, domain 1search PF01370: NAD dependent epimerase/dehydratase familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P32055) 'de novo' GDP-L-fucose biosynthetic processsearch metabolic processsearch oxidation-reduction processsearch colanic acid biosynthetic processsearch catalytic activitysearch GDP-L-fucose synthase activitysearch NADP+ bindingsearch oxidoreductase activitysearch isomerase activitysearch coenzyme bindingsearch cytoplasmsearch

Chain InterPro annotation
A NAD-dependent epimerase/dehydratase, N-terminal domainsearch NAD(P)-binding domainsearch GDP-L-fucose synthasesearch