1e79 Summary

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Bovine F1-ATPase inhibited by DCCD (dicyclohexylcarbodiimide)

The structure was published by Gibbons, C., Montgomery, M.G., Leslie, A.G.W., and Walker, J.E., in 2000 in a paper entitled "The Structure of the Central Stalk in Bovine F(1)-ATPase at 2.4 A Resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This entry contains 31 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterononamer.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ATP SYNTHASE ALPHA CHAIN HEART ISOFORM P19483 (44-553) (ATPA_BOVIN)search Bos taurussearch 92% 510 96%
B ATP SYNTHASE ALPHA CHAIN HEART ISOFORM P19483 (44-553) (ATPA_BOVIN)search Bos taurussearch 92% 510 96%
C ATP SYNTHASE ALPHA CHAIN HEART ISOFORM P19483 (44-553) (ATPA_BOVIN)search Bos taurussearch 92% 510 96%
D ATP SYNTHASE BETA CHAIN P00829 (47-528) (ATPB_BOVIN)search Bos taurussearch 91% 482 96%
E ATP SYNTHASE BETA CHAIN P00829 (47-528) (ATPB_BOVIN)search Bos taurussearch 91% 482 96%
F ATP SYNTHASE BETA CHAIN P00829 (47-528) (ATPB_BOVIN)search Bos taurussearch 91% 482 96%
G ATP SYNTHASE GAMMA CHAIN P05631 (26-297) (ATPG_BOVIN)search Bos taurussearch 91% 272 96%
H ATP SYNTHASE DELTA CHAIN P05630 (23-168) (ATPD_BOVIN)search Bos taurussearch 100% 146 89%
I ATP SYNTHASE EPSILON CHAIN P05632 (2-51) (ATP5E_BOVIN)search Bos taurussearch 92% 50 94%


This entry contains 5 unique UniProt proteins:

UniProt accession Name Organism PDB
P19483 (44 - 553) ATP SYNTHASE ALPHA CHAIN HEART ISOFORM Bos taurus
P00829 (47 - 528) ATP SYNTHASE BETA CHAIN Bos taurus
P05631 (26 - 297) ATP SYNTHASE GAMMA CHAIN Bos taurus
P05630 (23 - 168) ATP SYNTHASE DELTA CHAIN Bos taurus
P05632 (2 - 51) ATP SYNTHASE EPSILON CHAIN Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C (P19483) C-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, N-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, RecA protein-like (ATPase-domain)search Elongation Factor Tu (Ef-tu); domain 3search, P-loop containing nucleotide triphosphate hydrolasessearch, Lysinsearch PF00006: ATP synthase alpha/beta family, nucleotide-binding domainsearch, PF00306: ATP synthase alpha/beta chain, C terminal domainsearch, PF02874: ATP synthase alpha/beta family, beta-barrel domainsearch
D, E, F (P00829) C-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, N-terminal domain of alpha and beta subunits of F1 ATP synthasesearch, RecA protein-like (ATPase-domain)search Thrombin, subunit Hsearch, P-loop containing nucleotide triphosphate hydrolasessearch, Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3search PF00006: ATP synthase alpha/beta family, nucleotide-binding domainsearch, PF00306: ATP synthase alpha/beta chain, C terminal domainsearch, PF02874: ATP synthase alpha/beta family, beta-barrel domainsearch
G (P05631) ATP synthase (F1-ATPase), gamma subunitsearch Helix Hairpinssearch, Pyruvate Kinase; Chain: A, domain 1search PF00231: ATP synthasesearch
H (P05630) Epsilon subunit of F1F0-ATP synthase C-terminal domainsearch, Epsilon subunit of F1F0-ATP synthase N-terminal domainsearch ATP Synthase; domain 1search, Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch PF02823: ATP synthase, Delta/Epsilon chain, beta-sandwich domainsearch
I (P05632) Epsilon subunit of mitochondrial F1F0-ATP synthasesearch Atp Synthase Epsilon Chain; Chain: I;search PF04627: Mitochondrial ATP synthase epsilon chainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C (P19483) mitochondrial proton-transporting ATP synthase complexsearch mitochondrial inner membranesearch proton-transporting ATP synthase complex, catalytic core F(1)search proton-transporting two-sector ATPase complex, catalytic domainsearch plasma membranesearch mitochondrionsearch membranesearch ion transportsearch ATP metabolic processsearch ATP hydrolysis coupled proton transportsearch ATP synthesis coupled proton transportsearch ATP biosynthetic processsearch proton transportsearch transportsearch proton-transporting ATP synthase activity, rotational mechanismsearch ATP bindingsearch proton-transporting ATPase activity, rotational mechanismsearch nucleotide bindingsearch protein bindingsearch hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancessearch
D, E, F (P00829) membranesearch mitochondrionsearch mitochondrial proton-transporting ATP synthase complexsearch mitochondrial membranesearch proton-transporting two-sector ATPase complex, catalytic domainsearch plasma membranesearch extracellular vesicular exosomesearch mitochondrial inner membranesearch nucleussearch mitochondrial nucleoidsearch proton-transporting ATP synthase complex, catalytic core F(1)search cell surfacesearch ATP hydrolysis coupled proton transportsearch ATP biosynthetic processsearch proton transportsearch ion transportsearch angiogenesissearch negative regulation of cell adhesion involved in substrate-bound cell migrationsearch lipid metabolic processsearch ATP synthesis coupled proton transportsearch ATP metabolic processsearch osteoblast differentiationsearch transportsearch regulation of intracellular pHsearch ATP catabolic processsearch MHC class I protein bindingsearch hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancessearch proton-transporting ATP synthase activity, rotational mechanismsearch ATP bindingsearch proton-transporting ATPase activity, rotational mechanismsearch hydrolase activitysearch nucleotide bindingsearch protein bindingsearch ATPase activitysearch
G (P05631) mitochondrial inner membranesearch proton-transporting ATP synthase complex, catalytic core F(1)search extracellular vesicular exosomesearch mitochondrionsearch membranesearch mitochondrial proton-transporting ATP synthase complexsearch proton transportsearch ATP catabolic processsearch ATP synthesis coupled proton transportsearch ion transportsearch transportsearch ATP biosynthetic processsearch poly(A) RNA bindingsearch proton-transporting ATPase activity, rotational mechanismsearch proton-transporting ATP synthase activity, rotational mechanismsearch ATPase activitysearch protein bindingsearch
H (P05630) proton-transporting ATP synthase complex, catalytic core F(1)search ATP synthesis coupled proton transportsearch proton-transporting ATP synthase activity, rotational mechanismsearch proton-transporting ATPase activity, rotational mechanismsearch
I (P05632) mitochondrionsearch membranesearch proton-transporting ATP synthase complex, catalytic core F(1)search mitochondrial inner membranesearch mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)search mitochondrial proton-transporting ATP synthase complexsearch ion transportsearch transportsearch ATP synthesis coupled proton transportsearch proton transportsearch ATP biosynthetic processsearch proton-transporting ATP synthase activity, rotational mechanismsearch proton-transporting ATPase activity, rotational mechanismsearch

Chain InterPro annotation
A, B, C ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainsearch ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminalsearch ATPase, F1 complex alpha/beta subunit, N-terminal domainsearch ATPase, F1 complex, alpha subunitsearch ATPase, alpha/beta subunit, nucleotide-binding domain, active sitesearch ATP synthase subunit alpha-like domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
D, E, F ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainsearch ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminalsearch AAA+ ATPase domainsearch ATPase, F1 complex alpha/beta subunit, N-terminal domainsearch ATPase, F1 complex, beta subunitsearch ATPase, alpha/beta subunit, nucleotide-binding domain, active sitesearch ATPase, F1 complex beta subunit/V1 complex, C-terminalsearch P-loop containing nucleoside triphosphate hydrolasesearch
G ATPase, F1 complex, gamma subunitsearch ATPase, F1 complex, gamma subunit conserved sitesearch ATPase, F1 complex, gamma subunit domainsearch
H ATPase, F1 complex, delta/epsilon subunitsearch ATPase, F1 complex, delta/epsilon subunit, N-terminalsearch ATPase, F1 complex, delta/epsilon subunit, C-terminal domainsearch
I ATPase, F1 complex, epsilon subunit, mitochondrialsearch