› 1e75

Solution NMR

NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1 POINT MUTATION VARIANT R7L

Released:
DOI: 10.2210/pdb1e75/pdb
PDB entry 1e75 coloured by chain, ensemble of 20 models, front view.
PDB entry 1e75 coloured by chain, ensemble of 20 models, side view.
PDB entry 1e75 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus imperialis
Primary publication:
Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist.
Rogers JP, Luginbühl P, Pemberton K, Harty P, Wemmer DE, Stevens RC
J Mol Biol 304 911-26 (2000)
PMID: 11124036

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin ImI Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.31 KDa
Source organism: Conus imperialis
Expression system: Not provided
UniProt:
  • Canonical: P50983 (Residues: 5-16; Coverage: 71%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: TORSION ANGLE DYNAMICS, RESTRAINED ENERGY MINIMISATION
Expression system: Not provided

Quick links

Citations

8 review citations

Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes.
Nicke et al. (2004)
7 more

3 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
2 more