1e6e Summary

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ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS

The structure was published by Mueller, J.J., Lapko, A., Bourenkov, G., Ruckpaul, K., and Heinemann, U., in 2001 in a paper entitled "Adrenodoxin Reductase-Adrenodoxin Complex Structure Suggests Electron Transfer Path in Steroid Biosynthesis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely NADPH\:ADRENODOXIN OXIDOREDUCTASE and ADRENODOXIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NADPH\:ADRENODOXIN OXIDOREDUCTASE P08165 (33-492) (ADRO_BOVIN)search Bos taurussearch 93% 460 99%
C NADPH\:ADRENODOXIN OXIDOREDUCTASE P08165 (33-492) (ADRO_BOVIN)search Bos taurussearch 93% 460 99%
B ADRENODOXIN P00257 (59-186) (ADX_BOVIN)search Bos taurussearch < 90% 128 88%
D ADRENODOXIN P00257 (59-186) (ADX_BOVIN)search Bos taurussearch < 90% 128 88%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P08165 (33 - 492) NADPH\:ADRENODOXIN OXIDOREDUCTASE Bos taurus
P00257 (59 - 186) ADRENODOXIN Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P08165) C-terminal domain of adrenodoxin reductase-likesearch, N-terminal domain of adrenodoxin reductase-likesearch NAD(P)-binding Rossmann-like Domainsearch, FAD/NAD(P)-binding domainsearch
B, D 2Fe-2S ferredoxin-relatedsearch Ubiquitin-like (UB roll)search 2Fe-2S iron-sulfur cluster binding domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P08165) oxidation-reduction processsearch steroid biosynthetic processsearch lipid metabolic processsearch cholesterol metabolic processsearch steroid metabolic processsearch mitochondrionsearch mitochondrial matrixsearch protein bindingsearch oxidoreductase activitysearch ferredoxin-NADP+ reductase activitysearch flavin adenine dinucleotide bindingsearch NADP bindingsearch
B, D (P00257) electron carrier activitysearch iron-sulfur cluster bindingsearch 2 iron, 2 sulfur cluster bindingsearch

Chain InterPro annotation
A, C NAD(P)-binding domainsearch Adrenodoxin-NADP+ reductasesearch
B, D 2Fe-2S ferredoxin-type domainsearch Adrenodoxinsearch Beta-grasp domainsearch Adrenodoxin, iron-sulphur binding sitesearch