1dxv Summary

pdbe.org/1dxv
spacer

HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch bicarbonate transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen transporter activitysearch iron ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch
B, D (P68871) small molecule metabolic processsearch platelet aggregationsearch nitric oxide transportsearch transportsearch oxidation-reduction processsearch renal absorptionsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch positive regulation of cell deathsearch blood coagulationsearch oxygen transportsearch regulation of blood pressuresearch bicarbonate transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch heme bindingsearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch