1dxv Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) extracellular regionsearch membranesearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch protein bindingsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch receptor-mediated endocytosissearch bicarbonate transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxygen transportsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch oxidation-reduction processsearch
B, D (P68871) hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch transportsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch platelet aggregationsearch small molecule metabolic processsearch regulation of blood pressuresearch oxidation-reduction processsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch positive regulation of cell deathsearch blood coagulationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch