1dxv Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch cytosolsearch extracellular regionsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch endocytic vesicle lumensearch membranesearch cytosolic small ribosomal subunitsearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch small molecule metabolic processsearch transportsearch bicarbonate transportsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch protein heterooligomerizationsearch
B, D (P68871) hemoglobin complexsearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch extracellular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch iron ion bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen transportsearch small molecule metabolic processsearch regulation of blood pressuresearch nitric oxide transportsearch platelet aggregationsearch regulation of blood vessel sizesearch renal absorptionsearch hydrogen peroxide catabolic processsearch blood coagulationsearch protein heterooligomerizationsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch bicarbonate transportsearch receptor-mediated endocytosissearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch