1dxu Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch cytosolsearch membranesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch bicarbonate transportsearch response to hydrogen peroxidesearch transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch oxygen transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch
B, D (P68871) heme bindingsearch oxygen bindingsearch protein bindingsearch iron ion bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch oxygen transportsearch positive regulation of cell deathsearch blood coagulationsearch renal absorptionsearch platelet aggregationsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch bicarbonate transportsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch regulation of blood vessel sizesearch oxidation-reduction processsearch nitric oxide transportsearch protein heterooligomerizationsearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch