1dxu Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (3 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) endocytic vesicle lumensearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch hemoglobin complexsearch cytosolsearch membranesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch bicarbonate transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxygen transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch heme bindingsearch oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch
B, D (P68871) hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch platelet aggregationsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch oxygen transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch blood coagulationsearch bicarbonate transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch transportsearch protein heterooligomerizationsearch regulation of blood pressuresearch small molecule metabolic processsearch nitric oxide transportsearch oxidation-reduction processsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch heme bindingsearch haptoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch