1dxt Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (1-147) (HBB_HUMAN)search Homo sapienssearch 98% 147 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (1-147) (HBB_HUMAN)search Homo sapienssearch 98% 147 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (1 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch oxygen transportsearch transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch bicarbonate transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch membranesearch
B, D (P68871) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch hemoglobin bindingsearch metal ion bindingsearch oxygen transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch nitric oxide transportsearch protein heterooligomerizationsearch blood coagulationsearch regulation of blood vessel sizesearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch renal absorptionsearch regulation of blood pressuresearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch extracellular regionsearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch