1dxt Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxy recombinant human hemoglobins synthesized from beta-globins having mutated amino termini." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (1-147) (HBB_HUMAN)search Homo sapienssearch 98% 147 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (1-147) (HBB_HUMAN)search Homo sapienssearch 98% 147 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (1 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin complexsearch membranesearch extracellular regionsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch bicarbonate transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch oxygen transportsearch transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch small molecule metabolic processsearch
B, D (P68871) oxygen bindingsearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch extracellular regionsearch hemoglobin complexsearch blood microparticlesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolsearch haptoglobin-hemoglobin complexsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch nitric oxide transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch response to hydrogen peroxidesearch transportsearch blood coagulationsearch renal absorptionsearch regulation of blood pressuresearch platelet aggregationsearch regulation of blood vessel sizesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch