1dwo Summary

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CRYSTAL STRUCTURE OF HYDROXYNITRILE LYASE FROM MANIHOT ESCULENTA IN COMPLEX WITH SUBSTRATES ACETONE AND CHLOROACETONE:IMPLICATIONS FOR THE MECHANISM OF CYANOGENESIS

The structure was published by Lauble, H., Forster, S., Miehlich, B., Wajant, H., and Effenberger, F., in 2001 in a paper entitled "Structure of Hydroxynitrile Lyase from Manihot Esculenta in Complex with Substrates Acetone and Chloroacetone: Implications for the Mechanism of Cyanogenesis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of HYDROXYNITRILE LYASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HYDROXYNITRILE LYASE P52705 (2-258) (HNL_MANES)search Manihot esculentasearch 100% 262 100%
B HYDROXYNITRILE LYASE P52705 (2-258) (HNL_MANES)search Manihot esculentasearch 100% 262 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P52705 (2 - 258) HYDROXYNITRILE LYASE Manihot esculenta

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P52705) Hydroxynitrile lyase-likesearch Rossmann foldsearch PF00561: alpha/beta hydrolase foldsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P52705) aromatic (S)-hydroxynitrile lyase activitysearch lyase activitysearch aliphatic (S)-hydroxynitrile lyase activitysearch metabolic processsearch

Chain InterPro annotation
A, B Alpha/beta hydrolase fold-1search Alpha/Beta hydrolase foldsearch