1dve Summary



The structure was published by Sugishima, M., Omata, Y., Kakuta, Y., Sakamoto, H., Noguchi, M., and Fukuyama, K., in 2000 in a paper entitled "Crystal structure of rat heme oxygenase-1 in complex with heme." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of HEME OXYGENASE-1. This molecule has the UniProt identifier P06762 (HMOX1_RAT)search. The sample contained 267 residues which is 92% of the natural sequence. Out of 267 residues 214 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEME OXYGENASE-1 P06762 (1-267) (HMOX1_RAT)search Rattus norvegicussearch 90% 267 80%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06762 (1 - 267) HEME OXYGENASE-1 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P06762) Eukaryotic type heme oxygenasesearch Heme Oxygenase; Chain Asearch PF01126: Heme oxygenasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P06762) heme oxidationsearch oxidation-reduction processsearch negative regulation of neuron apoptotic processsearch intrinsic apoptotic signaling pathway in response to DNA damagesearch positive regulation of angiogenesissearch response to oxidative stresssearch small GTPase mediated signal transductionsearch cellular response to nutrientsearch negative regulation of DNA bindingsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch heme catabolic processsearch response to hydrogen peroxidesearch regulation of transcription from RNA polymerase II promoter in response to oxidative stresssearch regulation of sequence-specific DNA binding transcription factor activitysearch negative regulation of smooth muscle cell proliferationsearch wound healing involved in inflammatory responsesearch erythrocyte homeostasissearch response to estrogensearch cellular response to cadmium ionsearch negative regulation of cell proliferationsearch apoptotic processsearch negative regulation of extrinsic apoptotic signaling pathway via death domain receptorssearch negative regulation of sequence-specific DNA binding transcription factor activitysearch negative regulation of mast cell cytokine productionsearch response to hypoxiasearch negative regulation of mast cell degranulationsearch phospholipid metabolic processsearch iron ion homeostasissearch cellular response to hypoxiasearch cellular response to arsenic-containing substancesearch angiogenesissearch cell deathsearch intracellular signal transductionsearch protein homooligomerizationsearch heme metabolic processsearch negative regulation of muscle cell apoptotic processsearch regulation of blood pressuresearch positive regulation of smooth muscle cell proliferationsearch response to nicotinesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch membranesearch nucleussearch cytosolsearch nucleolussearch caveolasearch plasma membranesearch enzyme bindingsearch phospholipase D activitysearch heme oxygenase (decyclizing) activitysearch signal transducer activitysearch heme bindingsearch protein bindingsearch protein homodimerization activitysearch oxidoreductase activitysearch metal ion bindingsearch

Chain InterPro annotation
A Haem oxygenasesearch Haem oxygenase-likesearch Haem oxygenase-like, multi-helicalsearch Haem oxygenase conserved sitesearch