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2-ENOYL-COA HYDRATASE, DATA COLLECTED AT 100 K, PH 6.5

The structure was published by Engel, C.K., Mathieu, M., Zeelen, J.P., Hiltunen, J.K., and Wierenga, R.K., in 1996 in a paper entitled "Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of 2-ENOYL-COA HYDRATASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 2-ENOYL-COA HYDRATASE P14604 (30-290) (ECHM_RAT)search Rattus norvegicussearch 90% 261 99%
B 2-ENOYL-COA HYDRATASE P14604 (30-290) (ECHM_RAT)search Rattus norvegicussearch 90% 261 99%
C 2-ENOYL-COA HYDRATASE P14604 (30-290) (ECHM_RAT)search Rattus norvegicussearch 90% 261 99%
D 2-ENOYL-COA HYDRATASE P14604 (30-290) (ECHM_RAT)search Rattus norvegicussearch 90% 261 99%
E 2-ENOYL-COA HYDRATASE P14604 (30-290) (ECHM_RAT)search Rattus norvegicussearch 90% 261 99%
F 2-ENOYL-COA HYDRATASE P14604 (30-290) (ECHM_RAT)search Rattus norvegicussearch 90% 261 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14604 (30 - 290) 2-ENOYL-COA HYDRATASE Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F (P14604) Crotonase-likesearch 2-enoyl-CoA Hydratase; Chain A, domain 1search, Lyase 2-enoyl-coa Hydratase, Chain A, domain 2search PF00378: Enoyl-CoA hydratase/isomerase familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D, E, F (P14604) fatty acid beta-oxidationsearch fatty acid metabolic processsearch lipid metabolic processsearch metabolic processsearch enoyl-CoA hydratase activitysearch lyase activitysearch catalytic activitysearch mitochondrionsearch mitochondrial matrixsearch

Chain InterPro annotation
A, B, C, D, E, F Crotonase superfamilysearch Enoyl-CoA hydratase/isomerase, conserved sitesearch ClpP/crotonase-like domainsearch