1du0 Summary

pdbe.org/1du0
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ENGRAILED HOMEODOMAIN Q50A VARIANT DNA COMPLEX

The structure was published by Grant, R.A., Rould, M.A., Klemm, J.D., and Pabo, C.O., in 2000 in a paper entitled "Exploring the role of glutamine 50 in the homeodomain-DNA interface: crystal structure of engrailed (Gln50 --> ala) complex at 2.0 A." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3'), and ENGRAILED HOMEODOMAIN.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENGRAILED HOMEODOMAIN P02836 (456-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 57 98%
B ENGRAILED HOMEODOMAIN P02836 (456-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 57 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02836 (456 - 512) ENGRAILED HOMEODOMAIN Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Homeodomainsearch Homeodomain-likesearch Homeobox domainsearch, Engrailed homeobox C-terminal signature domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P02836) sequence-specific DNA bindingsearch DNA bindingsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B Helix-turn-helix motifsearch Homeobox domainsearch Homeodomain-likesearch Homeobox, conserved sitesearch Homeodomain, metazoasearch