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PDBe Entry: 1dtq view

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
Summary
Header HYDROLASE/TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.8 Å, R-factor: 21.3%, Free R-factor: 29.5%, Spacegroup: P 21 21 21
Released 20/03/2000, deposition: 13/01/2000, last revision: 24/02/2009
Authors Ren, J.search; Diprose, J.search; Warren, J.search; Esnouf, R.M.search; Bird, L.E.search; Ikemizu, S.search; Slater, M.search; Milton, J.search; Balzarini, J.search; Stuart, D.I.search; Stammers, D.K.search
Primary citation Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
J.BIOL.CHEM.search vol:275, pag:5633-5639 (2000) [PubMed ID 10681546 ]search
Keywords HIV-1 reverse transcriptase AIDSsearch, non-nucleoside inhibitorsearch, drug designsearch, HYDROLASE/TRANSFERASE COMPLEXsearch
EC 2.7.7.49 ExPASy BRENDA search 2.7.7.7 ExPASy BRENDA search 3.1.26.4 ExPASy BRENDA search 3.4.23.16 ExPASy BRENDA search (A B)
Organism Human immunodeficiency virus 1 11676search(A B)
UniProt Gag-Pol polyprotein (Pr160Gag-Pol) [Contains: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (Retropepsin) (PR); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT); p51 RT; p15; Integrase (IN)] P04585search (A B)
Solvent A, B
Related entries 1rtv, 1rth, 1vru, 1rti, 1rtj, 1rev, 1rt1, 1rt2, 1klm, 1rt3, 1rt4, 1rt5, 1rt6, 1rt7, 1c0t, 1c0u, 1c1b, 1c1c, 1dtt
Polymers
Id Name Type UniProt Residues Observed
A HIV-1 RT A-CHAIN Protein P04585 (POL_HV1H2)search
 560 93%
B HIV-1 RT B-CHAIN Protein P04585 (POL_HV1H2)search
 440 91%
Heterogens
Id Name Ligands
A N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-NITRILOMETHYL-PYRIDYL]-THIOUREA FPT search
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