1dsz Summary

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STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1

The structure was published by Rastinejad, F., Wagner, T., Zhao, Q., and Khorasanizadeh, S., in 2000 in a paper entitled "Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RETINOIC ACID RECEPTOR ALPHA P10276 (82-167) (RARA_HUMAN)search Homo sapienssearch < 90% 86 87%
B RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (129-212) (RXRA_HUMAN)search Homo sapienssearch 98% 85 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P10276 (82 - 167) RETINOIC ACID RECEPTOR ALPHA Homo sapiens
P19793 (129 - 212) RETINOIC ACID RECEPTOR RXR-ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search
B (P19793) Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch PF00105: Zinc finger, C4 type (two domains)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P10276) sequence-specific DNA bindingsearch steroid hormone receptor activitysearch calcitriol receptor activitysearch zinc ion bindingsearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch
B (P19793) zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch calcitriol receptor activitysearch DNA bindingsearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch
B Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch