PDB entry 1dsy

C2 DOMAIN FROM PROTEIN KINASE C (ALPHA) COMPLEXED WITH CA2+ AND PHOSPHATIDYLSERINE

Download PDB file View in 3D Similar structures Quaternary structure

The structure was published by Verdaguer, N., Corbalan-Garcia, S., Ochoa, W.F., Fita, I., and Gomez-Fernandez, J.C., in 1999 in a paper entitled "Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN KINASE C, ALPHA TYPE. This molecule has the UniProt identifier P05696 (KPCA_RAT). The sample contained 139 residues which is < 90% of the natural sequence. Out of 139 residues 134 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain	Name	UniProt	Name of source organism	% of UniProt sequence present in the sample	Residues in the sample molecules	% of residues observed
A	PROTEIN KINASE C, ALPHA TYPE	P05696 (155-293) (KPCA_RAT)	Rattus norvegicus	< 90%	139	98%

This entry contains 1 unique UniProt protein:

UniProt accession	Name	Organism	PDB
P05696 (155 - 293)	PROTEIN KINASE C, ALPHA TYPE	Rattus norvegicus	Related PDB sequences UniProt coverage

Chain	Structural classification (SCOP)	Structural classification (CATH)	Sequence family (Pfam)
A	Synaptotagmin-like (S variant)	C2- domain Calcium/lipid binding domain	C2 domain, Phorbol esters/diacylglycerol binding domain (C1 domain), Protein kinase domain, Protein kinase C terminal domain

Chain ID	Molecular function (GO)
A	Protein binding

Chain

InterPro annotation

A

C2 calcium-dependent membrane targeting, Protein kinase, catalytic domain, AGC-kinase, C-terminal, Protein kinase C-like, phorbol ester/diacylglycerol binding, Serine/threonine- / dual-specificity protein kinase, catalytic domain, Serine/threonine-protein kinase, active site, C2 calcium/lipid-binding domain, CaLB, Protein kinase-like domain, Protein kinase C, alpha/beta/gamma types, Protein kinase, ATP binding site, Protein kinase, C-terminal, C2 membrane targeting protein, Diacylglycerol/phorbol-ester binding, C2 domain