1ds2 Summary



The structure was published by Bateman, K.S., Huang, K., Anderson, S., et al., Qasim, M.A., Laskowski Jr., M., and James, M.N., in 2001 in a paper entitled "Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Pro18I and OMTKY3-psi[COO]-Leu18I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi[CH2NH2+]-Asp19I" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEINASE B (SGPB) and OVOMUCOID.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E PROTEINASE B (SGPB) P00777 (115-299) (PRTB_STRGR)search Streptomyces griseussearch < 90% 185 100%
I OVOMUCOID P68390 (135-185) (IOVO_MELGA)search Meleagris gallopavosearch 100% 51 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00777 (115 - 299) PROTEINASE B (SGPB) Streptomyces griseus
P68390 (135 - 185) OVOMUCOID Meleagris gallopavo

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E Prokaryotic proteasessearch Trypsin-like serine proteasessearch Trypsinsearch
I (P68390) Ovomucoid domain III-likesearch Wheat Germ Agglutinin (Isolectin 2); domain 1search PF00050: Kazal-type serine protease inhibitor domainsearch

Chain ID Biological process (GO) Molecular function (GO)
E (P00777) proteolysissearch serine-type endopeptidase activitysearch catalytic activitysearch
I (P68390) serine-type endopeptidase inhibitor activitysearch

Chain InterPro annotation
E Peptidase S1search Peptidase S1A, streptogrisinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
I Proteinase inhibitor I1, Kazal metazoasearch Kazal domainsearch