1dqa Summary details

pdbe.org/1dqa/summary_details
spacer COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.0 Å, R-factor: 16.8%, Free R-factor: 19.7%, Spacegroup: P 1 21 1
Released 08/03/2000, deposition: 30/12/1999, last revision: 24/02/2009
Authors Istvan, E.S.search; Palnitkar, M.search; Buchanan, S.K.search; Deisenhofer, J.search
Primary citation Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
EMBO J.search vol:19, pag:819-830 (2000) [PubMed 10698924 ]search
Keywords OXIDOREDUCTASEsearch, CHOLESTEROL BIOSYNTHESISsearch, HMG-COAsearch, NADPHsearch
EC 1.1.1.34 ExPASy BRENDA search (C D A B)
Organism Homo sapiens(human) 9606search(A B C D)
UniProt P04035search (A B C D)
Solvent A, B, C, D
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B, C, D PROTEIN (HMG-COA REDUCTASE) Protein P04035 (HMDH_HUMAN)search
467 87%
Heterogens
Chain Id Name Ligands
A, B, C, D COENZYME A COA search
A, B, D, C 3-HYDROXY-3-METHYL-GLUTARIC ACID MAH search
A, B, C, D NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE NAP search
spacer