spacer COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+
UniProt sequence   UniProt   CATH   Pfam   SCOP   Secondary structure   UniProt features   FASTA string  

Chain A: PROTEIN (HMG-COA REDUCTASE)

1 G A M A S S V L V T Q E P E I E L P R E P R P N E E C L Q I L G N A E K G A K F L S D A E I I Q L V N A K H I P A Y K L
S S V L V T Q E P E I E L P R E P R P N E E C L Q I L G N A E K G A K F L S D A E I I Q L V N A K H I P A Y K L
426
61 E T L I E T H E R G V S I R R Q L L S K K L S E P S S L Q Y L P Y R D Y N Y S L V M G A C C E N V I G Y M P I P V G V A
E T L M E T H E R G V S I R R Q L L S K K L S E P S S L Q Y L P Y R D Y N Y S L V M G A C C E N V I G Y M P I P V G V A
121 G P L C L D E K E F Q V P M A T T E G C L V A S T N R G C R A I G L G G G A S S R V L A D G M T R G P V V R L P R A C D
G P L C L D E K E F Q V P M A T T E G C L V A S T N R G C R A I G L G G G A S S R V L A D G M T R G P V V R L P R A C D
181 S A E V K A W L E T S E G F A V I K E A F D S T S R F A R L Q K L H T S I A G R N L Y I R F Q S R S G D A M G M N M I S
S A E V K A W L E T S E G F A V I K E A F D S T S R F A R L Q K L H T S I A G R N L Y I R F Q S R S G D A M G M N M I S
241 K G T E K A L S K L H E Y F P E M Q I L A V S G N Y C T D K K P A A I N W I E G R G K S V V C E A V I P A K V V R E V L
K G T E K A L S K L H E Y F P E M Q I L A V S G N Y C T D K K P A A I N W I E G R G K S V V C E A V I P A K V V R E V L
301 K T T T E A M I E V N I N K N L V G S A M A G S I G G Y N A H A A N I V T A I Y I A C G Q D A A Q N V G S S N C I T L M
K T T T E A M I E V N I N K N L V G S A M A G S I G G Y N A H A A N I V T A I Y I A C G Q D A A Q N V G S S N C I T L M
361 E A S G P T N E D L Y I S C T M P S I E I G T V G G G T N L L P Q Q A C L Q M L G V Q G A C K D N P G E N A R Q L A R I
E A S G P T N E D L Y I S C T M P S I E I G T V G G G T N L L P Q Q A C L Q M L G V Q G A C K D N P G E N A R Q L A R I
421 V C G T V M A G E L S L M A A L A A G H L V K S H M I H N R S K I N L Q D L Q G A C T K K T A
V C G T V M A G E L S L M A A L A A G H L V K S H M I H N R S K I N L Q D L Q G A C T K K T A
888

Regions

UniProt

P04035
426 .. 888 > 426 .. 888 (PDB)

Pfam

PF00368
489 .. 871 (PDB)

Chain B: PROTEIN (HMG-COA REDUCTASE)

1 G A M A S S V L V T Q E P E I E L P R E P R P N E E C L Q I L G N A E K G A K F L S D A E I I Q L V N A K H I P A Y K L
S S V L V T Q E P E I E L P R E P R P N E E C L Q I L G N A E K G A K F L S D A E I I Q L V N A K H I P A Y K L
426
61 E T L I E T H E R G V S I R R Q L L S K K L S E P S S L Q Y L P Y R D Y N Y S L V M G A C C E N V I G Y M P I P V G V A
E T L M E T H E R G V S I R R Q L L S K K L S E P S S L Q Y L P Y R D Y N Y S L V M G A C C E N V I G Y M P I P V G V A
121 G P L C L D E K E F Q V P M A T T E G C L V A S T N R G C R A I G L G G G A S S R V L A D G M T R G P V V R L P R A C D
G P L C L D E K E F Q V P M A T T E G C L V A S T N R G C R A I G L G G G A S S R V L A D G M T R G P V V R L P R A C D
181 S A E V K A W L E T S E G F A V I K E A F D S T S R F A R L Q K L H T S I A G R N L Y I R F Q S R S G D A M G M N M I S
S A E V K A W L E T S E G F A V I K E A F D S T S R F A R L Q K L H T S I A G R N L Y I R F Q S R S G D A M G M N M I S
241 K G T E K A L S K L H E Y F P E M Q I L A V S G N Y C T D K K P A A I N W I E G R G K S V V C E A V I P A K V V R E V L
K G T E K A L S K L H E Y F P E M Q I L A V S G N Y C T D K K P A A I N W I E G R G K S V V C E A V I P A K V V R E V L
301 K T T T E A M I E V N I N K N L V G S A M A G S I G G Y N A H A A N I V T A I Y I A C G Q D A A Q N V G S S N C I T L M
K T T T E A M I E V N I N K N L V G S A M A G S I G G Y N A H A A N I V T A I Y I A C G Q D A A Q N V G S S N C I T L M
361 E A S G P T N E D L Y I S C T M P S I E I G T V G G G T N L L P Q Q A C L Q M L G V Q G A C K D N P G E N A R Q L A R I
E A S G P T N E D L Y I S C T M P S I E I G T V G G G T N L L P Q Q A C L Q M L G V Q G A C K D N P G E N A R Q L A R I
421 V C G T V M A G E L S L M A A L A A G H L V K S H M I H N R S K I N L Q D L Q G A C T K K T A
V C G T V M A G E L S L M A A L A A G H L V K S H M I H N R S K I N L Q D L Q G A C T K K T A
888

Regions

UniProt

P04035
426 .. 888 > 426 .. 888 (PDB)

Pfam

PF00368
489 .. 871 (PDB)

Chain C: PROTEIN (HMG-COA REDUCTASE)

1 G A M A S S V L V T Q E P E I E L P R E P R P N E E C L Q I L G N A E K G A K F L S D A E I I Q L V N A K H I P A Y K L
S S V L V T Q E P E I E L P R E P R P N E E C L Q I L G N A E K G A K F L S D A E I I Q L V N A K H I P A Y K L
426
61 E T L I E T H E R G V S I R R Q L L S K K L S E P S S L Q Y L P Y R D Y N Y S L V M G A C C E N V I G Y M P I P V G V A
E T L M E T H E R G V S I R R Q L L S K K L S E P S S L Q Y L P Y R D Y N Y S L V M G A C C E N V I G Y M P I P V G V A
121 G P L C L D E K E F Q V P M A T T E G C L V A S T N R G C R A I G L G G G A S S R V L A D G M T R G P V V R L P R A C D
G P L C L D E K E F Q V P M A T T E G C L V A S T N R G C R A I G L G G G A S S R V L A D G M T R G P V V R L P R A C D
181 S A E V K A W L E T S E G F A V I K E A F D S T S R F A R L Q K L H T S I A G R N L Y I R F Q S R S G D A M G M N M I S
S A E V K A W L E T S E G F A V I K E A F D S T S R F A R L Q K L H T S I A G R N L Y I R F Q S R S G D A M G M N M I S
241 K G T E K A L S K L H E Y F P E M Q I L A V S G N Y C T D K K P A A I N W I E G R G K S V V C E A V I P A K V V R E V L
K G T E K A L S K L H E Y F P E M Q I L A V S G N Y C T D K K P A A I N W I E G R G K S V V C E A V I P A K V V R E V L
301 K T T T E A M I E V N I N K N L V G S A M A G S I G G Y N A H A A N I V T A I Y I A C G Q D A A Q N V G S S N C I T L M
K T T T E A M I E V N I N K N L V G S A M A G S I G G Y N A H A A N I V T A I Y I A C G Q D A A Q N V G S S N C I T L M
361 E A S G P T N E D L Y I S C T M P S I E I G T V G G G T N L L P Q Q A C L Q M L G V Q G A C K D N P G E N A R Q L A R I
E A S G P T N E D L Y I S C T M P S I E I G T V G G G T N L L P Q Q A C L Q M L G V Q G A C K D N P G E N A R Q L A R I
421 V C G T V M A G E L S L M A A L A A G H L V K S H M I H N R S K I N L Q D L Q G A C T K K T A
V C G T V M A G E L S L M A A L A A G H L V