1dp7 Summary

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COCRYSTAL STRUCTURE OF RFX-DBD IN COMPLEX WITH ITS COGNATE X-BOX BINDING SITE

The structure was published by Gajiwala, K.S., Chen, H., Cornille, F., et al., Reith, W., Mach, B., and Burley, S.K., in 2000 in a paper entitled "Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely DNA (5'-D(*CP*GP*(BRU)P*TP*AP*CP*CP*AP*(BRU)P*GP*GP*TP*AP*AP*CP*G)-3') and MHC CLASS II TRANSCRIPTION FACTOR HRFX1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
P MHC CLASS II TRANSCRIPTION FACTOR HRFX1 P22670 (438-513) (RFX1_HUMAN)search Homo sapienssearch < 90% 76 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22670 (438 - 513) MHC CLASS II TRANSCRIPTION FACTOR HRFX1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
P P4 origin-binding domain-likesearch "winged helix" repressor DNA binding domainsearch RFX DNA-binding domainsearch
Chain InterPro annotation
P DNA-binding RFX-type winged-helix domainsearch Winged helix-turn-helix DNA-binding domainsearch