1do8 Summary

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CRYSTAL STRUCTURE OF A CLOSED FORM OF HUMAN MITOCHONDRIAL NAD(P)+-DEPENDENT MALIC ENZYME

The structure was published by Yang, Z., Floyd, D.L., Loeber, G., and Tong, L., in 2000 in a paper entitled "Structure of a closed form of human malic enzyme and implications for catalytic mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of MALIC ENZYME.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MALIC ENZYME P23368 (21-584) (MAOM_HUMAN)search Homo sapienssearch 94% 564 98%
B MALIC ENZYME P23368 (21-584) (MAOM_HUMAN)search Homo sapienssearch 94% 564 98%
C MALIC ENZYME P23368 (21-584) (MAOM_HUMAN)search Homo sapienssearch 94% 564 98%
D MALIC ENZYME P23368 (21-584) (MAOM_HUMAN)search Homo sapienssearch 94% 564 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23368 (21 - 584) MALIC ENZYME Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P23368) Aminoacid dehydrogenase-like, C-terminal domainsearch, Malic enzyme N-domainsearch Aminoacid dehydrogenase-like, N-terminal domain. Chain Asearch, NAD(P)-binding Rossmann-like Domainsearch PF00390: Malic enzyme, N-terminal domainsearch, PF03949: Malic enzyme, NAD binding domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B, C, D (P23368) mitochondrionsearch mitochondrial matrixsearch intracellular membrane-bounded organellesearch catalytic activitysearch NAD bindingsearch malate dehydrogenase (decarboxylating) (NAD+) activitysearch malic enzyme activitysearch oxaloacetate decarboxylase activitysearch electron carrier activitysearch oxidoreductase activitysearch metal ion bindingsearch oxidation-reduction processsearch malate metabolic processsearch metabolic processsearch

Chain InterPro annotation
A, B, C, D Malic oxidoreductasesearch Malic enzyme, N-terminal domainsearch Malic enzyme, NAD-bindingsearch Malic enzyme, conserved sitesearch NAD(P)-binding domainsearch