1dm2 Summary

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HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE

The structure was published by Meijer, L., Thunnissen, A.M., White, A.W., et al., Mandelkow, E.M., Kim, S.H., and Pettit, G.R., in 2000 in a paper entitled "Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein bindingsearch metal ion bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch cyclin bindingsearch transferase activitysearch nucleotide bindingsearch histone kinase activitysearch protein phosphorylationsearch blood coagulationsearch positive regulation of DNA-dependent DNA replication initiationsearch G2/M transition of mitotic cell cyclesearch cellular response to DNA damage stimulussearch histone phosphorylationsearch mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic G1 DNA damage checkpointsearch regulation of gene silencingsearch Ras protein signal transductionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to nitric oxidesearch potassium ion transportsearch mitotic nuclear divisionsearch meiotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch positive regulation of cell proliferationsearch cell divisionsearch cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch centrosome duplicationsearch DNA replicationsearch phosphorylationsearch DNA repairsearch nucleoplasmsearch cytoplasmsearch endosomesearch Cajal bodysearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch nucleussearch centrosomesearch chromosome, telomeric regionsearch cytoskeletonsearch X chromosomesearch transcription factor complexsearch Y chromosomesearch condensed chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch