1dlh Summary

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CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE

The structure was published by Stern, L.J., Brown, J.H., Jardetzky, T.S., et al., Urban, R.G., Strominger, J.L., and Wiley, D.C., in 1994 in a paper entitled "Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (ALPHA CHAIN), CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (BETA CHAIN), and ENTEROTOXIN TYPE B PRECURSOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (ALPHA CHAIN) P01903 (28-207) (DRA_HUMAN)search Homo sapienssearch < 90% 180 100%
D CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (ALPHA CHAIN) P01903 (28-207) (DRA_HUMAN)search Homo sapienssearch < 90% 180 100%
B CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (BETA CHAIN) P04229 (32-219) (2B11_HUMAN)search Homo sapienssearch < 90% 188 100%
E CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (BETA CHAIN) P04229 (32-219) (2B11_HUMAN)search Homo sapienssearch < 90% 188 100%
C ENTEROTOXIN TYPE B PRECURSOR P04664 (306-318) (HEMA_I69A0)search Influenza A virus (A/England/878/1969(H3N2))search < 90% 13 100%
F ENTEROTOXIN TYPE B PRECURSOR P04664 (306-318) (HEMA_I69A0)search Influenza A virus (A/England/878/1969(H3N2))search < 90% 13 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (28 - 207) CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (ALPHA CHAIN) Homo sapiens
P04229 (32 - 219) CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (BETA CHAIN) Homo sapiens
P04664 (306 - 318) ENTEROTOXIN TYPE B PRECURSOR

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B, E C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C, F Haemagglutininsearch

Chain ID Cellular component (GO) Biological process (GO)
A, D (P01903) membranesearch MHC class II protein complexsearch immune responsesearch antigen processing and presentationsearch
B, E (P04229) MHC class II protein complexsearch membranesearch antigen processing and presentationsearch immune responsesearch

Chain InterPro annotation
A, D MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B, E MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C, F