1dl2 Summary



The structure was published by Vallee, F., Lipari, F., Yip, P., Sleno, B., Herscovics, A., and Howell, P.L., in 2000 in a paper entitled "Crystal structure of a class I alpha1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality control." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.54 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CLASS I ALPHA-1,2-MANNOSIDASE. This molecule has the UniProt identifier P32906 (MNS1_YEAST)search. The sample contained 511 residues which is 93% of the natural sequence. Out of 511 residues 508 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CLASS I ALPHA-1,2-MANNOSIDASE P32906 (34-549) (MNS1_YEAST)search Saccharomyces cerevisiae S288csearch 92% 511 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P32906 (34 - 549) CLASS I ALPHA-1,2-MANNOSIDASE Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P32906) Class I alpha-1;2-mannosidase, catalytic domainsearch Glycosyltransferasesearch PF01532: Glycosyl hydrolase family 47search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P32906) endoplasmic reticulumsearch endoplasmic reticulum membranesearch membranesearch integral component of membranesearch mannosyl-oligosaccharide 1,2-alpha-mannosidase activitysearch calcium ion bindingsearch hydrolase activity, acting on glycosyl bondssearch hydrolase activitysearch protein glycosylationsearch protein deglycosylation involved in glycoprotein catabolic processsearch ER-associated ubiquitin-dependent protein catabolic processsearch metabolic processsearch

Chain InterPro annotation
A Glycoside hydrolase, family 47search