1dku Summary

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CRYSTAL STRUCTURES OF BACILLUS SUBTILIS PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE: MOLECULAR BASIS OF ALLOSTERIC INHIBITION AND ACTIVATION.

The structure was published by Eriksen, T.A., Kadziola, A., Bentsen, A.K., Harlow, K.W., and Larsen, S., in 2000 in a paper entitled "Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE) P14193 (1-317) (KPRS_BACSU)search Bacillus subtilis subsp. subtilis str. 168search 100% 317 93%
B PROTEIN (PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE) P14193 (1-317) (KPRS_BACSU)search Bacillus subtilis subsp. subtilis str. 168search 100% 317 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14193 (1 - 317) PROTEIN (PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE) Bacillus subtilis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P14193) Phosphoribosylpyrophosphate synthetase-likesearch Rossmann foldsearch PF13793: N-terminal domain of ribose phosphate pyrophosphokinasesearch, PF14572: Phosphoribosyl synthetase-associated domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P14193) ribose phosphate diphosphokinase activitysearch magnesium ion bindingsearch kinase activitysearch metal ion bindingsearch transferase activitysearch ATP bindingsearch nucleotide bindingsearch nucleotide biosynthetic processsearch cellular biosynthetic processsearch ribonucleoside monophosphate biosynthetic processsearch phosphorylationsearch 5-phosphoribose 1-diphosphate biosynthetic processsearch cytoplasmsearch

Chain InterPro annotation
A, B Phosphoribosyl pyrophosphate synthetase, conserved sitesearch Ribose-phosphate diphosphokinasesearch Phosphoribosyltransferase-likesearch Ribose-phosphate pyrophosphokinase, N-terminal domainsearch