1dkg Summary

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CRYSTAL STRUCTURE OF THE NUCLEOTIDE EXCHANGE FACTOR GRPE BOUND TO THE ATPASE DOMAIN OF THE MOLECULAR CHAPERONE DNAK

The structure was published by Harrison, C.J., Hayer-Hartl, M., Di Liberto, M., Hartl, F., and Kuriyan, J., in 1997 in a paper entitled "Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely NUCLEOTIDE EXCHANGE FACTOR GRPE and MOLECULAR CHAPERONE DNAK.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NUCLEOTIDE EXCHANGE FACTOR GRPE P09372 (1-197) (GRPE_ECOLI)search Escherichia coli K-12search 100% 197 80%
B NUCLEOTIDE EXCHANGE FACTOR GRPE P09372 (1-197) (GRPE_ECOLI)search Escherichia coli K-12search 100% 197 80%
D MOLECULAR CHAPERONE DNAK P0A6Y8 (1-383) (DNAK_ECOLI)search Escherichia coli K-12search 95% 383 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P09372 (1 - 197) NUCLEOTIDE EXCHANGE FACTOR GRPE Escherichia coli
P0A6Y8 (1 - 383) MOLECULAR CHAPERONE DNAK Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P09372) Head domain of nucleotide exchange factor GrpEsearch, Coiled-coil domain of nucleotide exchange factor GrpEsearch Hemagglutinin Ectodomain; Chain Bsearch, Nucleotide Exchange Factor Grpe, Chain A, domain 2search PF01025: GrpEsearch
D (P0A6Y8) Actin/HSP70search Nucleotidyltransferase; domain 5search, Defensin A-likesearch, Actin; Chain A, domain 4search PF00012: Hsp70 proteinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P09372) response to heatsearch protein unfoldingsearch protein foldingsearch regulation of catalytic activitysearch response to stresssearch cytoplasmsearch protein homodimerization activitysearch chaperone bindingsearch adenyl-nucleotide exchange factor activitysearch

Chain InterPro annotation
A, B GrpE nucleotide exchange factorsearch GrpE nucleotide exchange factor, headsearch GrpE nucleotide exchange factor, coiled-coilsearch
D Heat shock protein 70 familysearch Heat shock protein 70, conserved sitesearch