1dkf Summary

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CRYSTAL STRUCTURE OF A HETERODIMERIC COMPLEX OF RAR AND RXR LIGAND-BINDING DOMAINS

The structure was published by Bourguet, W., Vivat, V., Wurtz, J.M., Chambon, P., Gronemeyer, H., and Moras, D., in 2000 in a paper entitled "Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (RETINOID X RECEPTOR-ALPHA) and PROTEIN (RETINOIC ACID RECEPTOR-ALPHA).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (RETINOID X RECEPTOR-ALPHA) P28700 (230-462) (RXRA_MOUSE)search Mus musculussearch < 90% 233 93%
B PROTEIN (RETINOIC ACID RECEPTOR-ALPHA) P10276 (182-416) (RARA_HUMAN)search Homo sapienssearch < 90% 235 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P28700 (230 - 462) PROTEIN (RETINOID X RECEPTOR-ALPHA) Mus musculus
P10276 (182 - 416) PROTEIN (RETINOIC ACID RECEPTOR-ALPHA) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P28700) zinc ion bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch
B (P10276) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch retinoic acid receptor activitysearch regulation of transcription, DNA-templatedsearch retinoic acid receptor signaling pathwaysearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Retinoic acid receptorsearch Nuclear hormone receptor, ligand-bindingsearch