1dke Summary

pdbe.org/1dke
spacer

NI BETA HEME HUMAN HEMOGLOBIN

The structure was published by Bruno, S., Bettati, S., Manfredini, M., et al., Tsuneshige, A., Yonetani, T., and Henry, E.R., in 2000 in a paper entitled "Oxygen binding by alpha(Fe2+)2beta(Ni2+)2 hemoglobin crystals." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN: ALPHA CHAIN and HEMOGLOBIN: BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN: ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN: ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN: BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN: BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN: ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN: BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch heme bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch oxygen bindingsearch hemoglobin complexsearch extracellular regionsearch membranesearch extracellular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch bicarbonate transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch oxygen transportsearch protein heterooligomerizationsearch transportsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch
B, D (P68871) heme bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch hemoglobin bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin complexsearch extracellular exosomesearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch oxygen transportsearch protein heterooligomerizationsearch bicarbonate transportsearch oxidation-reduction processsearch nitric oxide transportsearch transportsearch regulation of blood pressuresearch blood coagulationsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch small molecule metabolic processsearch response to hydrogen peroxidesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch