1djl Summary

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THE CRYSTAL STRUCTURE OF HUMAN TRANSHYDROGENASE DOMAIN III WITH BOUND NADP

The structure was published by White, S.A., Peake, S.J., McSweeney, S., Leonard, G., Cotton, N.P., and Jackson, J.B., in 2000 in a paper entitled "The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of TRANSHYDROGENASE DIII.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TRANSHYDROGENASE DIII Q13423 (880-1086) (NNTM_HUMAN)search Homo sapienssearch < 90% 207 87%
B TRANSHYDROGENASE DIII Q13423 (880-1086) (NNTM_HUMAN)search Homo sapienssearch < 90% 207 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13423 (880 - 1086) TRANSHYDROGENASE DIII Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Transhydrogenase domain III (dIII)search TPP-binding domainsearch NAD(P) transhydrogenase beta subunitsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q13423) cell redox homeostasissearch oxidation-reduction processsearch proton transportsearch NAD(P)+ transhydrogenase (AB-specific) activitysearch NADP bindingsearch NAD(P)+ transhydrogenase activitysearch mitochondrial inner membranesearch integral component of membranesearch

Chain InterPro annotation
A, B NADP transhydrogenase, beta subunitsearch DHS-like NAD/FAD-binding domainsearch NAD(P) transhydrogenase, mitochondrialsearch