› › Function and Biology

DIOL DEHYDRATASE-CYANOCOBALAMIN COMPLEX FROM KLEBSIELLA OXYTOCA

Source organism: Klebsiella oxytoca
Biochemical function: propanediol dehydratase activity
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 4.2.1.28: Propanediol dehydratase

Reaction catalysed:
Propane-1,2-diol = propanal + H(2)O
Systematic name:
Propane-1,2-diol hydro-lyase (propanal-forming)
Alternative Name(s):
  • 1,2-propanediol dehydratase
  • Adenosylcobalamin-dependent diol dehydratase
  • Coenzyme B12-dependent diol dehydrase
  • DL-1,2-propanediol hydro-lyase
  • Diol dehydrase
  • Diol dehydratase
  • Dioldehydratase
  • Meso-2,3-butanediol dehydrase
  • Propane-1,2-diol hydro-lyase
  • Propanediol dehydrase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02287
Domain description: Dehydratase small subunit
Occurring in:
  1. Diol dehydrase gamma subunit
The deposited structure of PDB entry 1dio contains 2 copies of Pfam domain PF02287 (Dehydratase small subunit) in Diol dehydrase gamma subunit. Showing 1 copy in chain C [auth G].

PF02288
Domain description: Dehydratase medium subunit
Occurring in:
  1. Diol dehydrase beta subunit
The deposited structure of PDB entry 1dio contains 2 copies of Pfam domain PF02288 (Dehydratase medium subunit) in Diol dehydrase beta subunit. Showing 1 copy in chain B.

PF02286
Domain description: Dehydratase large subunit
Occurring in:
  1. Diol/glycerol dehydratase large subunit domain-containing protein
The deposited structure of PDB entry 1dio contains 2 copies of Pfam domain PF02286 (Dehydratase large subunit) in Diol/glycerol dehydratase large subunit domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003206
Domain description: Diol/glycerol dehydratase, large subunit
Occurring in:
  1. Diol/glycerol dehydratase large subunit domain-containing protein
IPR036091
Domain description: Propanediol/glycerol dehydratase, small subunit superfamily
Occurring in:
  1. Diol dehydrase gamma subunit
IPR003207
Domain description: Propanediol/glycerol dehydratase, small subunit
Occurring in:
  1. Diol dehydrase gamma subunit
IPR010254
Domain description: B12-dependent dehydratases, beta subunit
Occurring in:
  1. Diol dehydrase beta subunit
IPR003208
Domain description: Diol/glycerol dehydratase/dehydratase reactivating factor
Occurring in:
  1. Diol dehydrase beta subunit
IPR025541
Domain description: Propanediol/glycerol dehydratase, medium subunit
Occurring in:
  1. Diol dehydrase beta subunit
IPR036999
Domain description: Diol/glycerol dehydratase, large subunit superfamily
Occurring in:
  1. Diol/glycerol dehydratase large subunit domain-containing protein
IPR016176
Domain description: Cobalamin (vitamin B12)-dependent enzyme, catalytic
Occurring in:
  1. Diol/glycerol dehydratase large subunit domain-containing protein

Structure domains

CATH CATH domains
1.10.1510.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Hypothetical Protein Yqey; Chain: A; domain1
Homology: Propanediol/glycerol dehydratase, small subunit
Occurring in:
  1. Diol dehydrase gamma subunit
The deposited structure of PDB entry 1dio contains 2 copies of CATH domain 1.10.1510.20 (Hypothetical Protein Yqey; Chain: A; domain1) in Diol dehydrase gamma subunit. Showing 1 copy in chain C [auth G].
3.40.50.10150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: B12-dependent dehydatase associated subunit
Occurring in:
  1. Diol dehydrase beta subunit
The deposited structure of PDB entry 1dio contains 2 copies of CATH domain 3.40.50.10150 (Rossmann fold) in Diol dehydrase beta subunit. Showing 1 copy in chain B.
3.20.20.350
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Diol/glycerol dehydratase, large subunit
Occurring in:
  1. Diol/glycerol dehydratase large subunit domain-containing protein
The deposited structure of PDB entry 1dio contains 2 copies of CATH domain 3.20.20.350 (TIM Barrel) in Diol/glycerol dehydratase large subunit domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotations
47149
Class: All alpha proteins
Fold: Open three-helical up-and-down bundle
Superfamily: Diol dehydratase, gamma subunit
Occurring in:
  1. Diol dehydrase gamma subunit
The deposited structure of PDB entry 1dio contains 2 copies of SCOP domain 47149 (Diol dehydratase, gamma subunit) in Diol dehydrase gamma subunit. Showing 1 copy in chain C [auth G].
52969
Class: Alpha and beta proteins (a/b)
Fold: Anticodon-binding domain-like
Superfamily: B12-dependent dehydatase associated subunit
Occurring in:
  1. Diol dehydrase beta subunit
The deposited structure of PDB entry 1dio contains 2 copies of SCOP domain 52969 (Diol dehydratase, beta subunit) in Diol dehydrase beta subunit. Showing 1 copy in chain B.
51710
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Cobalamin (vitamin B12)-dependent enzymes
Occurring in:
  1. Diol/glycerol dehydratase large subunit domain-containing protein
The deposited structure of PDB entry 1dio contains 2 copies of SCOP domain 51710 (Diol dehydratase, alpha subunit) in Diol/glycerol dehydratase large subunit domain-containing protein. Showing 1 copy in chain A.

Quick links