1di9 Summary

pdbe.org/1di9
spacer

THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE

The structure was published by Shewchuk, L., Hassell, A., Wisely, B., et al., Holmes, W., Veal, J., and Kuyper, L.F., in 2000 in a paper entitled "Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of P38 KINASE. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 344 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A P38 KINASE Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) P38 KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch intracellular signal transductionsearch toll-like receptor 10 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch glucose metabolic processsearch striated muscle cell differentiationsearch p38MAPK cascadesearch neurotrophin TRK receptor signaling pathwaysearch signal transduction in response to DNA damagesearch regulation of transcription from RNA polymerase II promotersearch regulation of transcription, DNA-templatedsearch MyD88-dependent toll-like receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch skeletal muscle tissue developmentsearch positive regulation of brown fat cell differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch apoptotic processsearch vascular endothelial growth factor receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of myoblast differentiationsearch cell morphogenesissearch toll-like receptor 5 signaling pathwaysearch positive regulation of protein import into nucleussearch toll-like receptor TLR1:TLR2 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch regulation of cytokine production involved in inflammatory responsesearch stress-induced premature senescencesearch toll-like receptor signaling pathwaysearch gene expressionsearch fatty acid oxidationsearch DNA damage checkpointsearch peptidyl-serine phosphorylationsearch cellular response to vascular endothelial growth factor stimulussearch toll-like receptor TLR6:TLR2 signaling pathwaysearch blood coagulationsearch Ras protein signal transductionsearch toll-like receptor 2 signaling pathwaysearch innate immune responsesearch cell surface receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch chondrocyte differentiationsearch cellular response to ionizing radiationsearch toll-like receptor 3 signaling pathwaysearch positive regulation of myotube differentiationsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of myoblast fusionsearch movement of cell or subcellular componentsearch positive regulation of cyclase activitysearch positive regulation of blood vessel endothelial cell migrationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cellular response to DNA damage stimulussearch osteoclast differentiationsearch phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch organelle organizationsearch signal transductionsearch activation of MAPK activitysearch positive regulation of muscle cell differentiationsearch stress-activated MAPK cascadesearch angiogenesissearch cartilage condensationsearch chemotaxissearch toll-like receptor 9 signaling pathwaysearch mitochondrion organizationsearch muscle cell differentiationsearch response to muramyl dipeptidesearch cellular response to lipopolysaccharidesearch platelet activationsearch response to lipopolysaccharidesearch transcription, DNA-templatedsearch ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch MAP kinase kinase activitysearch transferase activitysearch cellsearch nucleoplasmsearch nucleussearch extracellular exosomesearch cytosolsearch spindle polesearch cytoplasmsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch