THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE
The structure was published by Shewchuk, L., Hassell, A., Wisely, B., et al., Holmes, W., Veal, J., and Kuyper, L.F., in 2000 in a paper entitled "Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1999.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of P38 KINASE. This molecule has the UniProt identifier Q16539 (MK14_HUMAN). The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 344 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: