1di8 Summary

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THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE

The structure was published by Shewchuk, L., Hassell, A., Wisely, B., et al., Holmes, W., Veal, J., and Kuyper, L.F., in 2000 in a paper entitled "Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 281 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch histone phosphorylationsearch cell cyclesearch G1/S transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch mitotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch G2/M transition of mitotic cell cyclesearch Ras protein signal transductionsearch DNA repairsearch potassium ion transportsearch cellular response to nitric oxidesearch regulation of gene silencingsearch meiotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cell divisionsearch cellular response to DNA damage stimulussearch centrosome duplicationsearch blood coagulationsearch mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch phosphorylationsearch DNA replicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch protein serine/threonine kinase activitysearch cyclin bindingsearch transferase activitysearch kinase activitysearch histone kinase activitysearch nucleotide bindingsearch nucleoplasmsearch transcription factor complexsearch microtubule organizing centersearch Cajal bodysearch X chromosomesearch cytosolsearch endosomesearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch nucleussearch Y chromosomesearch cytoplasmsearch condensed chromosomesearch cytoskeletonsearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch