1dhf Summary



The structure was published by Davies 2nd., J.F., Delcamp, T.J., Prendergast, N.J., Ashford, V.A., Freisheim, J.H., and Kraut, J., in 1990 in a paper entitled "Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of DIHYDROFOLATE REDUCTASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DIHYDROFOLATE REDUCTASE P00374 (2-187) (DYR_HUMAN)search Homo sapienssearch 99% 186 97%
B DIHYDROFOLATE REDUCTASE P00374 (2-187) (DYR_HUMAN)search Homo sapienssearch 99% 186 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00374 (2 - 187) DIHYDROFOLATE REDUCTASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00374) Dihydrofolate reductasessearch Dihydrofolate Reductase, subunit Asearch PF00186: Dihydrofolate reductasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P00374) nitric oxide metabolic processsearch regulation of transcription involved in G1/S transition of mitotic cell cyclesearch tetrahydrofolate metabolic processsearch oxidation-reduction processsearch nucleotide biosynthetic processsearch glycine biosynthetic processsearch one-carbon metabolic processsearch tetrahydrofolate biosynthetic processsearch response to methotrexatesearch regulation of nitric-oxide synthase activitysearch mitotic cell cyclesearch water-soluble vitamin metabolic processsearch vitamin metabolic processsearch folic acid metabolic processsearch small molecule metabolic processsearch G1/S transition of mitotic cell cyclesearch dihydrofolate reductase activitysearch oxidoreductase activitysearch NADP bindingsearch drug bindingsearch mRNA bindingsearch RNA bindingsearch nucleoplasmsearch cytosolsearch cellular_componentsearch

Chain InterPro annotation
A, B Dihydrofolate reductase domainsearch Dihydrofolate reductasesearch Dihydrofolate reductase conserved sitesearch Dihydrofolate reductase-like domainsearch