1dgv Summary

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HOMOLOGY-BASED MODEL OF APO CIB (CALCIUM-AND INTEGRIN-BINDING PROTEIN)

The structure was published by Hwang, P.M. and Vogel, H.J., in 2000 in a paper entitled "Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of APO CIB. This molecule has the UniProt identifier Q99828 (CIB1_HUMAN)search. The sample contained 183 residues which is 96% of the natural sequence. Out of 183 residues 183 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A APO CIB Q99828 (9-191) (CIB1_HUMAN)search Homo sapienssearch 96% 183 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99828 (9 - 191) APO CIB Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH)
A (Q99828) Calmodulin-likesearch EF-handsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q99828) calcium ion bindingsearch protein bindingsearch metal ion bindingsearch ion channel bindingsearch Ras GTPase bindingsearch protein anchorsearch endomitotic cell cyclesearch positive regulation of metalloenzyme activitysearch positive regulation of protein serine/threonine kinase activitysearch positive regulation of protein phosphorylationsearch cellular response to growth factor stimulussearch negative regulation of neuron projection developmentsearch positive regulation of cell growthsearch thrombopoietin-mediated signaling pathwaysearch negative regulation of megakaryocyte differentiationsearch positive regulation of cell proliferationsearch positive regulation of cell migration involved in sprouting angiogenesissearch cellular response to DNA damage stimulussearch apoptotic processsearch negative regulation of protein phosphorylationsearch positive regulation of cell migrationsearch spermatid developmentsearch spermatogenesissearch cell adhesionsearch cellular response to nerve growth factor stimulussearch negative regulation of apoptotic processsearch positive regulation of protein targeting to membranesearch platelet formationsearch response to ischemiasearch positive regulation of calcineurin-NFAT signaling cascadesearch positive regulation of cell-matrix adhesionsearch positive regulation of establishment of protein localization to plasma membranesearch positive regulation of male germ cell proliferationsearch cell divisionsearch regulation of cell divisionsearch cell differentiationsearch positive regulation of ERK1 and ERK2 cascadesearch double-strand break repairsearch angiogenesissearch cellular response to tumor necrosis factorsearch extrinsic apoptotic signaling pathwaysearch negative regulation of protein kinase B signalingsearch negative regulation of cell proliferationsearch positive regulation of cell adhesion mediated by integrinsearch positive regulation of substrate adhesion-dependent cell spreadingsearch cell cyclesearch positive regulation of NF-kappaB transcription factor activitysearch regulation of cell proliferationsearch cytoplasmic microtubule organizationsearch negative regulation of microtubule depolymerizationsearch filopodium tipsearch microtubule organizing centersearch cytoplasmsearch plasma membranesearch membranesearch extracellular vesicular exosomesearch perinuclear region of cytoplasmsearch nucleussearch endoplasmic reticulumsearch Golgi apparatussearch cell peripherysearch neuronal cell bodysearch ruffle membranesearch apical plasma membranesearch growth conesearch nucleoplasmsearch sarcolemmasearch lamellipodiumsearch neuron projectionsearch cytoskeletonsearch centrosomesearch cell projectionsearch vesiclesearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch