1dgk Summary

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MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE

The structure was published by Aleshin, A.E., Kirby, C., Liu, X., et al., Bartunik, H.D., Fromm, H.J., and Honzatko, R.B., in 2000 in a paper entitled "Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of HEXOKINASE TYPE I. This molecule has the UniProt identifier P19367 (HXK1_HUMAN)search. The sample contained 917 residues which is 100% of the natural sequence. Out of 917 residues 898 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
N HEXOKINASE TYPE I P19367 (1-917) (HXK1_HUMAN)search Homo sapienssearch 100% 917 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19367 (1 - 917) HEXOKINASE TYPE I Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
N (P19367) Hexokinasesearch Nucleotidyltransferase; domain 5search, Hexokinase; domain 1search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
N (P19367) carbohydrate phosphorylationsearch glucose transportsearch carbohydrate metabolic processsearch cellular glucose homeostasissearch hexose transportsearch glycolytic processsearch cell deathsearch glucose 6-phosphate metabolic processsearch hexose metabolic processsearch transmembrane transportsearch metabolic processsearch small molecule metabolic processsearch phosphorylationsearch mitochondrial outer membranesearch membranesearch mitochondrionsearch cytosolsearch kinase activitysearch hexokinase activitysearch ATP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch mannokinase activitysearch catalytic activitysearch nucleotide bindingsearch glucokinase activitysearch protein bindingsearch fructokinase activitysearch transferase activitysearch

Chain InterPro annotation
N Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch