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PDBe Entry: 1df9 
DENGUE VIRUS NS3-PROTEASE COMPLEXED WITH MUNG-BEAN BOWMAN-BIRK INHIBITOR
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Viral protein/Viral protein inhibitor
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X-RAY DIFFRACTION
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Resolution: 2.1 Å, R-factor: 20.9%, Free R-factor: 24.3%, Spacegroup: P 21 21 21
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23/08/2000, deposition: 18/11/1999, last revision: 24/02/2009
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Krishna Murthy, H.M.; Judge, K.; DeLucas, L.; Padmanabhan, R.
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Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design.
J.MOL.BIOL. vol:301, pag:759-767 (2000) [PubMed ID 10966782 ]
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BETA BARRELS, CATALYTIC TRIAD, INHIBITOR COMPLEX, MULTIPLE CONFORMATION, VIRUS/VIRAL PROTEIN/INHIBITOR, Viral protein/Viral protein inhibitor COMPLEX
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2.1.1.56 ExPASy BRENDA 2.1.1.57 ExPASy BRENDA 2.7.7.48 ExPASy BRENDA 3.4.21.91 ExPASy BRENDA 3.6.1.15 ExPASy BRENDA (A B)
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Dengue virus 2 Jamaica/1409/1983 11064(A B),Vigna radiata var. radiata(mung bean) 3916(C)
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Genome polyprotein [Contains: Protein C (Core protein) (Capsid protein); prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Non-structural protein 2B); Serine protease subunit NS3 (EC 3.4.21.91) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.7.7.48) (EC 2.1.1.56) (Non-structural protein 5)] P14340 (A B)
Bowman-Birk type trypsin inhibitor P01062 (C)
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A, B, C
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| A, B |
NONSTRUCTURAL PROTEIN 1 |
Protein |
P14340 (POLG_DEN2N)
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191 |
92% |
| C |
BOWMAN-BIRK TYPE TRYPSIN INHIBITOR |
Protein |
P01062 (IBB_PHAAU)
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72 |
100% |
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