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EBI PDBe PDBeView

PDBe Entry: 1de9 view

HUMAN APE1 ENDONUCLEASE WITH BOUND ABASIC DNA AND MN2+ ION
Summary
Header LYASE/DNAsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.0 Å, R-factor: 18.31%, Free R-factor: 27.4%, Spacegroup: P 21 21 21
Released 02/02/2000, deposition: 13/11/1999, last revision: 24/02/2009
Authors Mol, C.D.search; Izumi, T.search; Mitra, S.search; Tainer, J.A.search
Primary citation DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
NATUREsearch vol:403, pag:451-456 (2000) [PubMed ID 10667800 ]search
Keywords ENZYME:DNA COMPLEXsearch, DNA REPAIR ABASIC SITEsearch, AP ENDONUCLEASEsearch, LYASE/DNA COMPLEXsearch
EC 4.2.99.18 ExPASy BRENDA search (A B)
Organism Homo sapiens(human) 9606search(A B)
UniProt DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APEX nuclease) (APEN) (Protein REF-1) P27695search (A B)
Related entries 1bix, 1de8
Polymers
Id Name Type UniProt Residues Observed
X, U 5'-d(*CP*TP*AP*C)-3' DNA
4 100%
Y, V 5'-d(P*(3DR)P*GP*AP*TP*C)-3' DNA
5 100%
Z, W 5'-d(*GP*AP*TP*CP*GP*GP*TP*AP*G)-3' DNA
9 100%
A, B MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE Protein P27695 (APEX1_HUMAN)search
 276 100%
Heterogens
Id Name Ligands
A, B MANGANESE (II) ION MN search
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