1de7 Summary

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INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA-THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX

The structure was published by Sadasivan, C. and Yee, V.C., in 2000 in a paper entitled "Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely ALPHA-THROMBIN (LIGHT CHAIN), ALPHA-THROMBIN (HEAVY CHAIN), and FACTOR XIII ACTIVATION PEPTIDE (28-37).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L ALPHA-THROMBIN (LIGHT CHAIN) P00734 (328-360) (THRB_HUMAN)search Homo sapienssearch 93% 36 77%
J ALPHA-THROMBIN (LIGHT CHAIN) P00734 (328-360) (THRB_HUMAN)search Homo sapienssearch 93% 36 77%
H ALPHA-THROMBIN (HEAVY CHAIN) P00734 (364-619) (THRB_HUMAN)search Homo sapienssearch 93% 259 96%
K ALPHA-THROMBIN (HEAVY CHAIN) P00734 (364-619) (THRB_HUMAN)search Homo sapienssearch 93% 259 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00734 (328 - 360) ALPHA-THROMBIN (LIGHT CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L, J (P00734) Eukaryotic proteasessearch PF09396: Thrombin light chainsearch
H, K (P00734) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
L, J (P00734) blood coagulationsearch proteolysissearch serine-type endopeptidase activitysearch extracellular regionsearch
H, K (P00734) blood coagulationsearch proteolysissearch serine-type endopeptidase activitysearch catalytic activitysearch calcium ion bindingsearch

Chain InterPro annotation
L, J Thrombin light chainsearch
H, K Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch