1ddx Summary

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CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE

The structure was published by Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., et al., Marnett, L.J., Stallings, W.C., and Kurumbail, R.G., in 2000 in a paper entitled "Structural insights into the stereochemistry of the cyclooxygenase reaction." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2) Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
B PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2) Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
C PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2) Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
D PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2) Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 569) PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2) Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (Q05769) peroxidase activitysearch heme bindingsearch prostaglandin-endoperoxide synthase activitysearch protein homodimerization activitysearch lipid bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch enzyme bindingsearch metal ion bindingsearch dioxygenase activitysearch oxidoreductase activitysearch response to oxidative stresssearch oxidation-reduction processsearch bone mineralizationsearch positive regulation of cell migration involved in sprouting angiogenesissearch response to estradiolsearch positive regulation of vasoconstrictionsearch response to lithium ionsearch response to organic cyclic compoundsearch anagensearch regulation of cell proliferationsearch cellular response to mechanical stimulussearch positive regulation of nitric oxide biosynthetic processsearch prostaglandin biosynthetic processsearch learningsearch lipid metabolic processsearch negative regulation of smooth muscle contractionsearch cellular response to hypoxiasearch positive regulation of smooth muscle contractionsearch positive regulation of platelet-derived growth factor productionsearch response to radiationsearch regulation of blood pressuresearch positive regulation of smooth muscle cell proliferationsearch positive regulation of apoptotic processsearch response to cytokinesearch brown fat cell differentiationsearch angiogenesissearch response to fructosesearch decidualizationsearch negative regulation of cell proliferationsearch positive regulation of fever generationsearch positive regulation of cell deathsearch cellular response to ATPsearch positive regulation of synaptic transmission, glutamatergicsearch maintenance of blood-brain barriersearch fatty acid biosynthetic processsearch response to vitamin Dsearch negative regulation of calcium ion transportsearch response to drugsearch positive regulation vascular endothelial growth factor productionsearch positive regulation of transforming growth factor beta productionsearch positive regulation of NF-kappaB import into nucleussearch positive regulation of synaptic plasticitysearch response to manganese ionsearch ovulationsearch cellular response to UVsearch fatty acid metabolic processsearch response to glucocorticoidsearch keratinocyte differentiationsearch response to organic substancesearch prostaglandin metabolic processsearch memorysearch cyclooxygenase pathwaysearch negative regulation of synaptic transmission, dopaminergicsearch response to fatty acidsearch response to tumor necrosis factorsearch embryo implantationsearch positive regulation of brown fat cell differentiationsearch response to lipopolysaccharidesearch hair cyclesearch positive regulation of fibroblast growth factor productionsearch sensory perception of painsearch response to organonitrogen compoundsearch inflammatory responsesearch negative regulation of cell cyclesearch cytoplasmsearch intracellular membrane-bounded organellesearch membranesearch organelle membranesearch neuron projectionsearch protein complexsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search