1dd1 Summary



The structure was published by Qin, B., Lam, S.S., and Lin, K., in 1999 in a paper entitled "Crystal structure of a transcriptionally active Smad4 fragment." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.62 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of SMAD4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SMAD4 Q13485 (285-552) (SMAD4_HUMAN)search Homo sapienssearch < 90% 268 92%
B SMAD4 Q13485 (285-552) (SMAD4_HUMAN)search Homo sapienssearch < 90% 268 92%
C SMAD4 Q13485 (285-552) (SMAD4_HUMAN)search Homo sapienssearch < 90% 268 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13485 (285 - 552) SMAD4 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C SMAD domainsearch Tumour Suppressor Smad4search MH2 domainsearch

Chain ID Cellular component (GO) Biological process (GO)
A, B, C (Q13485) intracellularsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B, C SMAD domain, Dwarfin-typesearch SMAD/FHA domainsearch Dwarfinsearch SMAD domain-likesearch