1dc2 Summary



The structure was published by Yuan, C., Selby, T.L., Li, J., Byeon, I.J., and Tsai, M.D., in 2000 in a paper entitled "Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1999.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (P16INK4A). This molecule has the UniProt identifier P42771 (CD2A1_HUMAN)search. The sample contained 156 residues which is 100% of the natural sequence. Out of 156 residues 156 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (P16INK4A) P42771 (1-156) (CD2A1_HUMAN)search Homo sapienssearch 100% 156 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42771 (1 - 156) CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (P16INK4A) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P42771) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00023: Ankyrin repeatsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P42771) negative regulation of phosphorylationsearch senescence-associated heterochromatin focus assemblysearch mitotic cell cyclesearch positive regulation of cellular senescencesearch negative regulation of NF-kappaB transcription factor activitysearch replicative senescencesearch cell cycle arrestsearch G1/S transition of mitotic cell cyclesearch negative regulation of cell proliferationsearch cell cyclesearch negative regulation of cell growthsearch negative regulation of transcription, DNA-templatedsearch negative regulation of cyclin-dependent protein serine/threonine kinase activitysearch cellular senescencesearch positive regulation of macrophage apoptotic processsearch negative regulation of cell-matrix adhesionsearch Ras protein signal transductionsearch positive regulation of smooth muscle cell apoptotic processsearch protein bindingsearch NF-kappaB bindingsearch protein kinase bindingsearch poly(A) RNA bindingsearch cyclin-dependent protein serine/threonine kinase inhibitor activitysearch cytosolsearch nucleussearch cytoplasmsearch senescence-associated heterochromatin focussearch

Chain InterPro annotation
A Ankyrin repeatsearch Ankyrin repeat-containing domainsearch